Rekombinanter BDKRB2 Antikörper

Produktnummer ABIN7880094

Der Kaninchen Monoklonal anti-BDKRB2 Antikörper wird verwendet zum Nachweis von BDKRB2 in Proben von Human und Maus. Er wurde validiert für WB, IHC und IP.

Kurzübersicht für Rekombinanter BDKRB2 Antikörper (ABIN7880094)

Target: BDKRB2 (Bradykinin Receptor B2 (BDKRB2))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser BDKRB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Klon: AFAG-2

Produktdetails anti-BDKRB2 Antikörper

Verwendungszweck: BDKRB2 Antibody / Bradykinin receptor B2

Aufreinigung: Affinity chromatography

Immunogen: A synthesized peptide derived from human BDKRB2 was used as the immunogen for the BDKRB2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the BDKRB2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the BDKRB2 antibody at -20oC.

Details zu BDKRB2

Target: BDKRB2 (Bradykinin Receptor B2 (BDKRB2))

Andere Bezeichnung: BDKRB2

Hintergrund: BDKRB2 antibody detects Bradykinin receptor B2, a G-protein-coupled receptor (GPCR) that mediates the physiological actions of bradykinin, a peptide involved in inflammation, vasodilation, and pain perception. The UniProt recommended name is Bradykinin receptor B2 (BDKRB2). This receptor is constitutively expressed in many tissues and acts as a key regulator of vascular tone, fluid balance, and inflammatory signaling.

Functionally, BDKRB2 antibody identifies a 364-amino-acid transmembrane receptor that activates intracellular signaling cascades upon bradykinin binding. The B2 receptor couples primarily to Gq and Gi proteins, triggering phospholipase C activation, intracellular calcium release, and nitric oxide production. This cascade promotes vasodilation, increases vascular permeability, and contributes to pain sensitization. BDKRB2 also regulates smooth muscle contraction and endothelial function through modulation of cyclic GMP pathways.

The BDKRB2 gene is located on chromosome 14q32.1 and encodes a receptor with seven transmembrane helices typical of GPCRs. Unlike the inducible B1 receptor, BDKRB2 is constitutively expressed under physiological conditions and mediates most acute responses to bradykinin. The receptor undergoes rapid desensitization and internalization upon agonist stimulation, allowing precise control of signal duration and intensity. BDKRB2 signaling is critical for cardiovascular regulation, renal function, and nociception.

In the vascular system, BDKRB2 activation stimulates endothelial nitric oxide synthase (eNOS), leading to vasorelaxation and reduced blood pressure. In the kidney, it modulates sodium excretion and renin release, linking it to salt balance and blood pressure homeostasis. Dysregulation of BDKRB2 expression or signaling contributes to hypertension, hereditary angioedema, and chronic inflammatory conditions. Polymorphisms in BDKRB2 have been associated with altered cardiovascular responses and endurance performance in humans.

Beyond vascular biology, BDKRB2 participates in neuroinflammation, pain transmission, and tumor biology. Its activation sensitizes nociceptive neurons and facilitates cross-talk with cytokine and prostaglandin pathways. In cancer, BDKRB2 expression promotes angiogenesis and cell migration, suggesting a role in tumor progression. Conversely, BDKRB2-mediated nitric oxide release can induce apoptosis under oxidative conditions, reflecting its context-dependent activity.

BDKRB2 antibody is used extensively in research on inflammation, vascular signaling, and neurobiology. It is suitable for immunoblotting, immunofluorescence, and receptor binding assays to detect expression patterns and subcellular localization. This antibody aids in studying GPCR signaling mechanisms and the pharmacological modulation of bradykinin pathways. NSJ Bioreagents provides BDKRB2 antibody reagents validated for use in cardiovascular, inflammatory, and neurophysiological research.

UniProt: P30411

Pathways: ACE Inhibitor Pathway, Negative Regulation of intrinsic apoptotic Signaling