Rekombinanter Centaurin beta 2 Antikörper

Produktnummer ABIN7879997

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch Centaurin beta 2 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für Rekombinanter Centaurin beta 2 Antikörper (ABIN7879997)

Target: Centaurin beta 2 (ACAP2) (ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 2 (ACAP2))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Centaurin beta 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 30A18

Produktdetails anti-Centaurin beta 2 Antikörper

Verwendungszweck: ACAP2 Antibody / ArfGAP with coiled-coil ankyrin repeat and PH domains 2

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human ACAP2 was used as the immunogen for the ACAP2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ACAP2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the ACAP2 antibody at -20oC.

Details zu Centaurin beta 2

Target: Centaurin beta 2 (ACAP2) (ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 2 (ACAP2))

Andere Bezeichnung: ACAP2

Hintergrund: ACAP2 antibody detects ArfGAP with coiled-coil, ankyrin repeat, and PH domains 2, a GTPase-activating protein that regulates ADP-ribosylation factor 6 (ARF6). ACAP2 controls membrane trafficking and actin cytoskeleton remodeling by accelerating the hydrolysis of ARF6-bound GTP. Through these functions, ACAP2 coordinates processes such as endocytosis, recycling, and cell migration.

Research using ACAP2 antibody demonstrates its role in neuronal and immune cell biology. In neurons, ACAP2 regulates dendritic spine development and axon guidance by modulating actin remodeling. In immune cells, ACAP2 contributes to receptor trafficking and migration, influencing both innate and adaptive responses. Dysregulation of ACAP2 has been associated with impaired immune function and altered neuronal connectivity.

ACAP2 is also studied in cancer and viral infections. Tumor cells exploit ARF6 signaling pathways to promote invasion and metastasis, and ACAP2 acts as a regulator of this activity. Reduced ACAP2 expression can enhance ARF6-mediated oncogenic signaling. Viral pathogens, including some RNA viruses, utilize ARF6 and its regulators to facilitate replication and budding, suggesting ACAP2 may indirectly impact host-pathogen interactions.

Antibodies against ACAP2 are validated for western blot, immunofluorescence, and immunohistochemistry. These reagents allow researchers to investigate protein localization, expression levels, and interactions with ARF6 and related molecules. Clone-based antibodies provide specificity to ensure consistent results across experimental systems.

NSJ Bioreagents supplies this ACAP2 antibody for studies in membrane trafficking, cytoskeletal regulation, and signaling pathways.

UniProt: Q15057