GNRHR Antikörper (N-Term)

Produktnummer ABIN7879608

Der Maus Monoklonal anti-GNRHR Antikörper wird verwendet zum Nachweis von GNRHR in Proben von Human. Er wurde validiert für ELISA.

Kurzübersicht für GNRHR Antikörper (N-Term) (ABIN7879608)

Target: GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GNRHR Antikörper ist unkonjugiert

Applikation: ELISA

Klon: A9E4

Produktdetails anti-GNRHR Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: GnRH-Receptor Antibody / LHCG Receptor

Sequenz: MANSASPEQN QHCSAINNSI PLMQGNLPY

Aufreinigung: Protein A/G affinity

Immunogen: amino acids MANSASPEQNQHCSAINNSIPLMQGNLPY from the N-terminal of human GnRH receptor was used as the immunogen for the GnRH-Receptor antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GnRH-Receptor antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the GnRH-Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu GNRHR

Target: GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))

Andere Bezeichnung: GnRH-Receptor

Hintergrund: Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.

UniProt: P30968