ARID3A Antikörper (N-Term)

Produktnummer ABIN7879562

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ARID3A in WB, IP und FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für ARID3A Antikörper (N-Term) (ABIN7879562)

Target: ARID3A (AT Rich Interactive Domain 3A (BRIGHT-Like) (ARID3A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARID3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS)

Produktdetails anti-ARID3A Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: ARID3A Antibody / AT-rich interactive domain-containing protein 3A

Aufreinigung: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human ARID3A was used as the immunogen for the ARID3A antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ARID3A antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the ARID3A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu ARID3A

Target: ARID3A (AT Rich Interactive Domain 3A (BRIGHT-Like) (ARID3A))

Andere Bezeichnung: ARID3A

Hintergrund: The ARID3A antibody targets AT-rich interactive domain-containing protein 3A, a nuclear transcription factor encoded by the ARID3A gene. Belonging to the ARID family of DNA-binding proteins, ARID3A regulates gene expression through chromatin remodeling and promoter activation. It binds specifically to AT-rich DNA sequences and modulates transcription during embryogenesis, hematopoietic development, and immune system differentiation. The ARID3A antibody enables researchers to study the protein's distribution, activity, and role in transcriptional networks that define cellular identity.

AT-rich interactive domain-containing protein 3A plays an essential role in B-cell development and immunoglobulin gene transcription. It promotes accessibility of heavy-chain enhancer regions and is crucial for the proper differentiation of pre-B and mature B lymphocytes. The ARID3A antibody is widely used in immunology and developmental biology research to assess how ARID3A expression correlates with cell fate and lineage commitment. Alterations in its expression have been associated with autoimmune disorders, hematological malignancies, and aberrant immune signaling pathways.

Beyond hematopoiesis, ARID3A contributes to embryonic patterning and organogenesis. It interacts with other chromatin regulators to influence developmental gene programs in neural and epithelial cells. Dysregulated expression can result in abnormal proliferation, reduced differentiation, and oncogenic transformation. The ARID3A antibody allows for high-resolution detection of this transcription factor in tissue and cell-based assays, helping define how ARID3A participates in chromatin remodeling, enhancer activation, and epigenetic memory.

In experimental use, the ARID3A antibody performs effectively in western blotting, immunofluorescence, chromatin immunoprecipitation, and immunohistochemistry. These applications reveal protein abundance, nuclear localization, and DNA-binding site occupancy. Through combination with transcriptomic analysis, the ARID3A antibody supports integrative studies of gene regulation, highlighting how AT-rich interactive domain-containing protein 3A interacts with co-factors to orchestrate transcriptional networks governing development and immunity.

ARID3A expression patterns are also linked to tumor progression and metastasis. Elevated or suppressed levels of the protein can influence tumor suppressor pathways and DNA repair mechanisms. The ARID3A antibody from NSJ Bioreagents is a reliable reagent for monitoring these expression shifts in cancer models, helping researchers connect transcription factor activity to oncogenic processes. Its consistent specificity across multiple assay types ensures reproducibility and accuracy in research findings.

By facilitating the study of AT-rich interactive domain-containing protein 3A, the ARID3A antibody continues to advance molecular understanding of chromatin organization and gene regulation. Its value extends from developmental and immunological research to clinical oncology, where deciphering ARID3A function may lead to improved diagnostics and targeted therapies. The antibody's consistent performance makes it an essential reagent for decoding the transcriptional architecture underlying human biology and disease.

UniProt: Q99856

Pathways: Chromatin Binding