ALDOC Antikörper (N-Term)

Produktnummer ABIN7879558

Der Kaninchen Polyklonal anti-ALDOC Antikörper (ABIN7879558) detektiert spezifisch ALDOC in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für ALDOC Antikörper (N-Term) (ABIN7879558)

Target: ALDOC (Aldolase C, Fructose-Bisphosphate (ALDOC))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALDOC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-ALDOC Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: ALDOC Antibody / Aldolase C

Aufreinigung: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Aldolase C/ALDOC was used as the immunogen for the ALDOC antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ALDOC antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the ALDOC antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu ALDOC

Target: ALDOC (Aldolase C, Fructose-Bisphosphate (ALDOC))

Andere Bezeichnung: ALDOC

Hintergrund: ALDOC antibody detects Aldolase C, a glycolytic enzyme involved in the reversible cleavage of fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate. Encoded by the ALDOC gene on chromosome 17q11.2, this protein is one of three aldolase isoenzymes (A, B, and C) expressed in a tissue-specific manner. Aldolase C is predominantly found in the brain and other neural tissues, where it supports both glycolytic energy metabolism and neuronal development.

Structurally, Aldolase C functions as a homotetramer with catalytic lysine residues that form Schiff bases with its substrate. It shares high sequence identity with Aldolase A (muscle type) and B (liver type) but exhibits unique kinetic properties suited for neuronal metabolism. In neurons and glial cells, Aldolase C contributes to glucose utilization, energy coupling, and maintenance of synaptic function. It also interacts with cytoskeletal proteins, suggesting roles beyond metabolism, including regulation of actin organization and cell morphology.

The ALDOC antibody is widely used in neuroscience, metabolism, and cell biology research to study glycolytic regulation and neural differentiation. Western blot analysis identifies a 39 kilodalton band corresponding to Aldolase C, while immunohistochemistry reveals strong cytoplasmic staining in Purkinje cells and astrocytes. This antibody supports investigation of metabolic compartmentalization and energy flux in the central nervous system.

Altered expression of Aldolase C has been observed in neurodegenerative diseases and gliomas, where metabolic reprogramming contributes to pathogenesis. Beyond the brain, ALDOC expression in epithelial and endocrine tissues suggests additional roles in energy balance and biosynthesis. The ALDOC antibody provides a reliable reagent for analyzing glycolytic enzyme distribution and function. NSJ Bioreagents offers this antibody validated for its applications, ensuring high specificity and reproducibility for metabolic and neurobiological studies.

UniProt: P09972