Der Kaninchen Monoklonal anti-Thrombomodulin Antikörper (Klon THBD-8188R) (ABIN7879141) detektiert spezifisch Thrombomodulin in IHC (p).
Dieser Antikörper reagiert spezifisch mit Proben aus Human.
THBD
Reaktivität: Human
WB, FACS, IF
Wirt: Kaninchen
Polyclonal
RB56919
unconjugated
Applikationshinweise
Optimal dilution of the CD141 antibody should be determined by the researcher.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
1 mg/mL
Buffer
1 mg/mL in 1X PBS, BSA free, sodium azide free
Konservierungsmittel
Azide free
Lagerung
-20 °C
Informationen zur Lagerung
Aliquot the CD141 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Target
Thrombomodulin (THBD)
Andere Bezeichnung
CD141
Hintergrund
It recognizes a protein of 75 kDa, identified as Thrombomodulin, or CD141. Thrombomodulin is a transmembrane glycoprotein with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytio-trophoblasts of placenta also express thrombomodulin. This protein is present in almost all of benign vascular tumors and majority of malignant vascular tumors (Kaposi s sarcoma, angiosarcoma, and epithelioid hemangioendothelioma). Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. Recently, thrombomodulin antibody has been used for mesothelial cells and malignant mesotheliomas.