Rekombinanter TCP1 alpha/CCTA Antikörper (full length)

Produktnummer ABIN7879125

Der Kaninchen Monoklonal anti-TCP1 alpha/CCTA Antikörper wird verwendet zum Nachweis von TCP1 alpha/CCTA in Proben von Human, Maus und Ratte. Er wurde validiert für WB und IHC (p).

Kurzübersicht für Rekombinanter TCP1 alpha/CCTA Antikörper (full length) (ABIN7879125)

Target: TCP1 alpha/CCTA (TCP1) (T-Complex 1 (TCP1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TCP1 alpha/CCTA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: TP63-1423R

Produktdetails anti-TCP1 alpha/CCTA Antikörper

Bindungsspezifität: full length

Verwendungszweck: Recombinant p63 Antibody / Rabbit Monoclonal (azide and preservative free)

Aufreinigung: Protein A affinity chromatography

Immunogen: Full-length human recombinant protein was used as the immunogen for the recombinant p63 antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant p63 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant p63 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu TCP1 alpha/CCTA

Target: TCP1 alpha/CCTA (TCP1) (T-Complex 1 (TCP1))

Andere Bezeichnung: p63

Hintergrund: P63 antibody targets Tumor protein 63, a transcription factor belonging to the p53 family that plays a central role in epithelial development, differentiation, and tissue homeostasis. Tumor protein 63 is primarily localized to the nucleus, where it functions as a DNA binding regulator of gene expression. p63 is highly expressed in basal and progenitor cells of stratified epithelia, including epidermis, prostate, urothelium, and respiratory epithelium, making it a widely used marker of epithelial stem and basal cell populations.

Tumor protein 63 is expressed as multiple isoforms generated through alternative promoter usage and splicing, broadly classified into transcriptionally active and dominant negative variants. A short functional summary is that p63 maintains epithelial progenitor cell identity and supports stratified epithelial integrity by regulating genes involved in proliferation, differentiation, and cell adhesion. Because of this fundamental role, p63 antibody reagents are essential tools in studies of epithelial biology and tissue architecture.

At the molecular level, Tumor protein 63 contains an N-terminal transactivation domain in certain isoforms, a central DNA binding domain, and a C-terminal oligomerization domain that enables tetramer formation. These structural features allow p63 to function as a transcriptional regulator and to interact with other members of the p53 family. p63 antibody tools are commonly used to examine nuclear localization, isoform expression patterns, and changes in epithelial differentiation status in both normal and diseased tissues.

From a disease relevance perspective, p63 is extensively used in diagnostic pathology as a marker to distinguish squamous cell carcinomas, basal-like tumors, and myoepithelial cells from other neoplastic entities. Altered expression or isoform imbalance of Tumor protein 63 has been implicated in cancer progression, epithelial dysplasia, and developmental disorders affecting ectoderm derived tissues. Clone TP63/1423R is designed to recognize Tumor protein 63 and support consistent detection of p63 expression in research and histological studies.

Developmentally, p63 expression is critical for epithelial stratification and limb and craniofacial morphogenesis. Loss of p63 function leads to severe defects in epithelial formation and maintenance. Recombinant rabbit antibody clone TP63/1423R provides a reliable research reagent for detecting Tumor protein 63 in studies of epithelial development, cancer biology, and tissue differentiation. p63 antibodies from NSJ Bioreagents are supplied as recombinant rabbit antibodies for research use to support investigations in cell biology and pathology.

UniProt: Q9H3D4