SMNDC1 Antikörper (full length)

Produktnummer ABIN7879100

Dieser Maus Monoklonal Antikörper detektiert spezifisch SMNDC1 in FACS und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für SMNDC1 Antikörper (full length) (ABIN7879100)

Target: SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SMNDC1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF)

Klon: PCRP-SMNDC1-1A9

Produktdetails anti-SMNDC1 Antikörper

Bindungsspezifität: full length

Verwendungszweck: SMNDC1 Antibody

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human SMNDC1 protein was used as the immunogen for the SMNDC1 antibody.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SMNDC1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the SMNDC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu SMNDC1

Target: SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))

Andere Bezeichnung: SMNDC1

Hintergrund: SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (survival motor neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.

UniProt: O75940