SPIC Antikörper (full length)

Produktnummer ABIN7879074

Der Maus Monoklonal anti-SPIC Antikörper wird verwendet zum Nachweis von SPIC in Proben von Human. Er wurde validiert für IF und FACS.

Kurzübersicht für SPIC Antikörper (full length) (ABIN7879074)

Target: SPIC (Spi-C Transcription Factor (Spi-1/PU.1 Related) (SPIC))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SPIC Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: PCRP-SPIC-2C5

Produktdetails anti-SPIC Antikörper

Bindungsspezifität: full length

Verwendungszweck: SPIC Antibody / Transcription factor Spi-C

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human Transcription factor Spi-C protein was used as the immunogen for the SPIC antibody.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SPIC antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the SPIC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu SPIC

Target: SPIC (Spi-C Transcription Factor (Spi-1/PU.1 Related) (SPIC))

Andere Bezeichnung: SPIC

Hintergrund: The Ets transcription factor family is comprised of DNA-binding proteins that influence lymphoid development and activity and bind the consensus DNA site GGA(A/T) through a unique winged helix-turn-helix motif known as the Ets domain. Spi-B and Spi-C (also known as SPIC) are closely related Ets family members which share a conserved divergent sequence within the Ets domain that enables their binding to non-canonical AGAA sites. Spi-C is a 248 amino acid protein that localizes to the nucleus and, like other Ets family members, binds DNA as a monomer and plays a role in transcriptional regulation. Addi- tionally, Spi-C is thought to control the development of red pulp macrophages, thereby contributing to iron homeostasis and red blood cell recycling. Human Spi-C shares 65 % amino acid identity with its mouse counterpart, suggesting a conserved role between species.

UniProt: Q8N5J4