SP100 Antikörper (full length)

Produktnummer ABIN7879068

Der Maus Monoklonal anti-SP100 Antikörper wird verwendet zum Nachweis von SP100 in Proben von Human. Er wurde validiert für WB, ELISA, IP, IF, FACS und IHC (p).

Kurzübersicht für SP100 Antikörper (full length) (ABIN7879068)

Target: SP100 (SP100 Nuclear Antigen (SP100))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SP100 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: PCRP-SP100-1B9

Produktdetails anti-SP100 Antikörper

Bindungsspezifität: full length

Verwendungszweck: SP100 Antibody

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human SP100 protein was used as the immunogen for the SP100 antibody.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SP100 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the SP100 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu SP100

Target: SP100 (SP100 Nuclear Antigen (SP100))

Andere Bezeichnung: SP100

Hintergrund: The human SP100 gene encodes an autoantigen that co-localizes with PML and NDP52 in distinct nuclear domains, called nuclear dots (NDs) or ND10 nuclear bodies. Papova-, adeno-, and herpesviruses begin their transcription and DNA-replication at NDs, which play a role in autoimmunity, viral infections and in the etiology of acute promyelocytic leukemia. SP-100 is an interferon inducible protein that has two splice variants. One splice variant contains a highly conserved copy of the DNA-binding high mobility group 1 protein sequence, and thus represents a novel HMG-box protein. This alternatively spliced variant of SP-100 has a unique expression and localization pattern that is distinct from the SP-100 full-length protein. The SP100 protein is covalently modified by the small ubiquitin-related protein SUMO-1. SP-100 contains a functional nuclear localization signal and an ND-targeting region, which overlaps with the SP-100 homodimerization domain.

UniProt: P23497

Pathways: Retinoic Acid Receptor Signaling Pathway