SATB1 Antikörper (full length)

Produktnummer ABIN7878974

Dieser Maus Monoklonal Antikörper detektiert spezifisch SATB1 in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für SATB1 Antikörper (full length) (ABIN7878974)

Target: SATB1 (SATB Homeobox 1 (SATB1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SATB1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: SATB1-2661

Produktdetails anti-SATB1 Antikörper

Bindungsspezifität: full length

Verwendungszweck: SATB1 Antibody / Special AT-rich sequence-binding protein 1 (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human SATB1 protein was used as the immunogen for the SATB1 antibody.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SATB1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the SATB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu SATB1

Target: SATB1 (SATB Homeobox 1 (SATB1))

Andere Bezeichnung: SATB1

Hintergrund: The homeoproteins CCAAT displacement protein (CDP) and special AT-rich sequence binding protein 1 (SATB1) are transcriptional repressors of many cellular genes, and they participate in cell development and cell type differentiation. SATB1 is expressed primarily in thymocytes, and, like CDP, it also contains a distinct homeobox DNA-binding domain that is essential for DNA binding. SATB1 and CDP interact through these homeodomains and synergistically function as mediators of gene expression. SATB1 contains an additional domain that has a higher affinity for DNA and specifically facilitates the direct association between SATB1 and the nuclear matrix attachment regions (MARs) of DNA. MARs are specific DNA sequences that bind to the nuclear matrix and form the base of chromosomal loops that organize the chromosomes and regulate DNA transcription and replication within the nucleus. The association of SATB1 with the core unwinding element within the base-unpairing region of MARs requires both the MAR and homeobox binding domains of SATB1.

UniProt: Q01826

Pathways: Caspase Kaskade in der Apoptose, Activated T Cell Proliferation