QKI Antikörper (full length)

Produktnummer ABIN7878887

Dieser Maus Monoklonal Antikörper detektiert spezifisch QKI in WB, IF, ELISA und FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für QKI Antikörper (full length) (ABIN7878887)

Target: QKI (Protein Quaking (QKI))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser QKI Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), ELISA, Flow Cytometry (FACS)

Klon: PCRP-QKI-2F10

Produktdetails anti-QKI Antikörper

Bindungsspezifität: full length

Verwendungszweck: QKI Antibody / Protein Quaking

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the QKI antibody.

Isotyp: IgG2c

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the QKI antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the QKI antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu QKI

Target: QKI (Protein Quaking (QKI))

Andere Bezeichnung: QKI

Hintergrund: QKI, also known as HKQ, QK, QK3 or quaking, is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, QKI functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5. Additionally, QKI regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. QKI may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases QKI mRNA-binding affinity. Defects or deletions in the gene encoding QKI are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of QKI exist due to alternative splicing events.

UniProt: Q96PU8