OTX2 Antikörper (full length)

Produktnummer ABIN7878766

Der Maus Monoklonal anti-OTX2 Antikörper (Klon PCRP-OTX2-1E10) (ABIN7878766) detektiert spezifisch OTX2 in ELISA und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für OTX2 Antikörper (full length) (ABIN7878766)

Target: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser OTX2 Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS)

Güteklasse: Carrier-free

Klon: PCRP-OTX2-1E10

Produktdetails anti-OTX2 Antikörper

Bindungsspezifität: full length

Verwendungszweck: OTX2 Antibody / Orthodenticle homolog 2 (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant human full-length OTX2 protein was used as the immunogen for the OTX2 antibody.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the OTX2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the OTX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu OTX2

Target: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Andere Bezeichnung: OTX2

Hintergrund: Transcription factors OTX1 and OTX2, two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q22.3, respectively.

UniProt: P32243

Pathways: Dopaminergic Neurogenesis