NMI Antikörper (full length)

Produktnummer ABIN7878699

Der Maus Monoklonal anti-NMI Antikörper wird verwendet zum Nachweis von NMI in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für NMI Antikörper (full length) (ABIN7878699)

Target: NMI (N-Myc (And STAT) Interactor (NMI))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NMI Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Güteklasse: Carrier-free

Klon: PCRP-NMI-1C1

Produktdetails anti-NMI Antikörper

Bindungsspezifität: full length

Verwendungszweck: N-Myc Interactor Antibody / NMI / N-myc and STAT interactor (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human N-Myc Interactor protein was used as the immunogen for the N-Myc Interactor antibody.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the N-Myc Interactor antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the N-Myc Interactor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu NMI

Target: NMI (N-Myc (And STAT) Interactor (NMI))

Andere Bezeichnung: N-Myc Interactor

Hintergrund: Nmi (for N-Myc interactor) is an interferon inducible protein that associates with multiple transcription factors, including c-Myc, n-Myc, Max, and c-Fos, which contain bHLH-ZIP, bHLH, or Zip domains. Nmi is ubiquitously expressed at low levels throughout various fetal and adult tissues and at higher levels in myeloid leukemias and cell lines overexpressing c-Myc. In addition to binding Myc proteins, Nmi also associates with the Stat family of transcription factors, where it enhances Stat-dependent transcription. Although Nmi lacks an intrinsic DNA binding or activation domain, Nmi enhances the transcriptional activity of the Stat proteins, in response to cytokine stimulation, by recruiting the Stat1 and Stat5 transcriptional coactivators, CREB-binding protein (CBP) and p300. In vitro studies indicate that Nmi, expressed in conjunction with CBP, enhances the transcriptional responsiveness of Stat5 to IL-2 stimulation five-fold over CBP alone by increasing the affinity of Stat proteins for CBP/p300.

UniProt: Q13287