Der Maus Monoklonal anti-MEF2D Antikörper (Klon PCRP-MEF2D-3A4) (ABIN7878688) detektiert spezifisch MEF2D in IHC (p), FACS und IF.
Dieser Antikörper reagiert spezifisch mit Proben aus Human.
MEF2D
Reaktivität: Human, Maus, Ratte
WB, ELISA, IF (cc), IF (p), IHC (p), FACS, IHC (fro)
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
Optimal dilution of the MEF2D antibody should be determined by the researcher.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
0.2 mg/mL
Buffer
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Aliquot the MEF2D antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Target
MEF2D
(Myocyte Enhancer Factor 2D (MEF2D))
Andere Bezeichnung
MEF2D
Hintergrund
The myocyte enhancer factor-2 (MEF-2) family of transcription factors associate with co-repessors or co-activators to regulate development and function of T cells, neuronal cells and muscle cells. Four family members arise from alternatively spliced transcripts, termed MEF-2A, -2B, -2C and -2D. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each duing embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including MyoD, myogenin, Myf-5 and MRF4, are one class of identified factors. A second family of DNA-binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF-2) family. Each of these proteins binds to the MEF-2 target DNA sequence present in the regulatory regions of many muscle-specific genes.