MPZ Antikörper (full length)

Produktnummer ABIN7878682

Der Maus Monoklonal anti-MPZ Antikörper (Klon MPZ-7390) (ABIN7878682) detektiert spezifisch MPZ in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MPZ Antikörper (full length) (ABIN7878682)

Target: MPZ (Myelin Protein Zero (MPZ))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MPZ Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: MPZ-7390

Produktdetails anti-MPZ Antikörper

Bindungsspezifität: full length

Verwendungszweck: MPZ Antibody / Myelin Protein Zero

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human MPZ protein was used as the immunogen for the MPZ antibody.

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MPZ antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the MPZ antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu MPZ

Target: MPZ (Myelin Protein Zero (MPZ))

Andere Bezeichnung: MPZ

Hintergrund: Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50 % of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.

UniProt: P25189