MBNL3 Antikörper (full length)

Produktnummer ABIN7878660

Der Maus Monoklonal anti-MBNL3 Antikörper wird verwendet zum Nachweis von MBNL3 in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für MBNL3 Antikörper (full length) (ABIN7878660)

Target: MBNL3 (Muscleblind-Like Splicing Regulator 3 (MBNL3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MBNL3 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: PCRP-MBNL3-1D11

Produktdetails anti-MBNL3 Antikörper

Bindungsspezifität: full length

Verwendungszweck: MBNL3 Antibody

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human MBNL3 protein was used as the immunogen for the MBNL3 antibody.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MBNL3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the MBNL3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu MBNL3

Target: MBNL3 (Muscleblind-Like Splicing Regulator 3 (MBNL3))

Andere Bezeichnung: MBNL3

Hintergrund: Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Several protein complexes are involved in proper mRNA splicing and transport. The muscleblind proteins, MBNL1, MBNL2 and MBNL3, promote inclusion or exclusion of specific exons on different pre-mRNAs by antagonizing the activity of CUG-BP and ETR-3-like factors bound to distinct intronic sites. MBNL1 and 2, which associate with expanded CUG repeats in vitro, localize to the nuclear foci in both DM1 and DM2 (myotonic dystrophy types 1 and 2), suggesting that the nuclear accumulation of mutant RNA is pathogenic in DM1, therefore implicating MBNL1 and 2 in the pathogenesis of both disorders. MBNL3, a 354 amino acid protein, inhibits expression of muscle differentiation, opposite to the function of MBNL1, which functions as a promoter of muscle differentiation. MBNL3 shows strong expression in placenta.

UniProt: Q9NUK0

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development