MXI1 Antikörper (full length)

Produktnummer ABIN7878586

Der Maus Monoklonal anti-MXI1 Antikörper (Klon PCRP-MXI1-1A3) (ABIN7878586) detektiert spezifisch MXI1 in WB, IF und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MXI1 Antikörper (full length) (ABIN7878586)

Target: MXI1 (MAX Interactor 1 (MXI1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MXI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Güteklasse: Carrier-free

Klon: PCRP-MXI1-1A3

Produktdetails anti-MXI1 Antikörper

Bindungsspezifität: full length

Verwendungszweck: MXI1 Antibody / Max-interacting protein 1 / BHLHC11 (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human MXI1 protein was used as the immunogen for the MXI1 antibody.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MXI1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the MXI1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu MXI1

Target: MXI1 (MAX Interactor 1 (MXI1))

Andere Bezeichnung: MXI1

Hintergrund: It is now well established that Myc regulation of cell proliferation and differentiation involves a family of related transcription factors. One such factor, Max, is an obligate heterodimeric partner for Myc and can also form heterodimers with at least four related proteins designated Mad 1, Mxi1 (also designated Mad 2), Mad 3 and Mad 4. Like Mad 1 and Mxi1, association of Mad 3 and Mad 4 with Max results in transcriptional repression. Both Myc and the Mad proteins have short half-lives and their synthesis is tightly regulated, while Max expression is constitutive and relatively stable. Two related mammalian cDNAs have been identified and shown to encode Mad- binding proteins. Both possess sequence homology with the yeast transcription repressor Sin3 including four conserved paired amphipathic helix (PAH) domains. mSin3A and mSin3B specifically interact with the Mad proteins via their second paired amphipathic helix domain (PAH2). It has been suggested that Mad-Max heterodimers repress transcription by tethering mSin3 to DNA as corepressors.

UniProt: P50539

Pathways: Maintenance of Protein Location