Keratin 10 Antikörper (full length)

Produktnummer ABIN7878475

Der Maus Monoklonal anti-Keratin 10 Antikörper (Klon KRT10-3861) (ABIN7878475) detektiert spezifisch Keratin 10 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Keratin 10 Antikörper (full length) (ABIN7878475)

Target: Keratin 10 (KRT10)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Keratin 10 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: KRT10-3861

Produktdetails anti-Keratin 10 Antikörper

Bindungsspezifität: full length

Verwendungszweck: Keratin 10 Antibody / Cytokeratin 10 / CK10

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human KRT10 protein was used as the immunogen for the Keratin 10 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Keratin 10 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Keratin 10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Keratin 10

Target: Keratin 10 (KRT10)

Andere Bezeichnung: Keratin 10

Hintergrund: This mAb recognizes a protein of 56.5 kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation, it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more differentiated parts.

UniProt: P13645