Rekombinanter Desmocollin 2+3 (full length) Antikörper

Produktnummer ABIN7878136

Der Kaninchen Monoklonal anti-Desmocollin 2+3 Antikörper (Klon DSC2-9165R) (ABIN7878136) detektiert spezifisch Desmocollin 2+3 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter Desmocollin 2+3 (full length) Antikörper (ABIN7878136)

Target: Desmocollin 2+3

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: DSC2-9165R

Produktdetails

Bindungsspezifität: full length

Verwendungszweck: Recombinant Desmocollin-2/3 Antibody (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human DSC2 protein was used as the immunogen for the recombinant Desmocollin-2/3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant Desmocollin-2/3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the recombinant Desmocollin-2/3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Antigendetails

Target: Desmocollin 2+3

Andere Bezeichnung: Desmocollin-2/3

Hintergrund: Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion. Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein 1-3 and desmocollins. Desmosomal cadherins showed differentiation-specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmocollin-1 can be found in the upper layers. The expression of desmocollin-2 varies in the basal and suprabasal layers. And desmocollin-3 is expressed more evenly throughout the suprabasal layers.

UniProt: Q02487