Chp2 Antikörper (full length)

Produktnummer ABIN7877978

Dieser Maus Monoklonal Antikörper detektiert spezifisch Chp2 in WB und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Chp2 Antikörper (full length) (ABIN7877978)

Target: Chp2

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Chp2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Güteklasse: Carrier-free

Klon: CPTC-CHP2-1

Produktdetails anti-Chp2 Antikörper

Bindungsspezifität: full length

Verwendungszweck: CHP2 Antibody / Calcineurin B homologous protein 2 (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: Recombinant human full-length protein was used as the immunogen for the CHP2 antibody.

Isotyp: IgG2c, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CHP2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the CHP2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Chp2

Target: Chp2

Hintergrund: CHP2 (calcineurin B homologous protein 2), also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.

UniProt: O43745