Rekombinanter CD34 Antikörper (full length)

Produktnummer ABIN7877870

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch CD34 in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter CD34 Antikörper (full length) (ABIN7877870)

Target: CD34

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CD34 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: HPCA1-8333R

Produktdetails anti-CD34 Antikörper

Bindungsspezifität: full length

Verwendungszweck: CD34 Antibody (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: Recombinant full-length human HPCA1 protein was used as the immunogen for the CD34 antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CD34 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the CD34 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu CD34

Target: CD34

Andere Bezeichnung: CD34

Hintergrund: CD34 (also named myeloid progenitor cell antigen) is a heavily glycosylated type I transmembrane protein. There are two forms of the CD34 protein, resulting from alternative splicing. The functions of CD34 is largely unknown, but recent evidence suggests a role for CD34 in cell adhesion and inhibition of hematopoiesis. It is suggested that CD34 is a signaling molecule involved in maintenance of a phenotypically plastic state in undifferentiated cells. CD34 is found in most endothelia, expressed on the luminal surface and membrane processes interdigitating between endothelial cells, but is absent from large veins and arteries. CD34 is furthermore expressed in fibroblast-like dendritic cells in, e.g., portal tracts of the liver, Peyer's patches, and in healing wounds. In smooth muscle cells, a variable CD34 staining is found. In tumor tissues, CD34 is detected in myeloid blasts in myelodysplastic syndrome and acute myeloid leukemia in most cases as well as lymphoblasts in most cases of B-acute lymphoblastic leukemia. Mature B- and T-cell lymphomas and leukemias are CD34 negative. The majority of vascular tumors, including hemangiosarcoma and Kaposi sarcoma are CD34positive. In a panel, CD34 staining is useful for the classification of myeloid and lymphoid neoplasms as well as spindle cell neoplasms (particularly identification of gastrointestinal stromal tumor and hemangiosarcoma).

UniProt: P28906