Calpain Antikörper (full length)

Produktnummer ABIN7877760

Der Maus Monoklonal anti-Calpain Antikörper wird verwendet zum Nachweis von Calpain in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Calpain Antikörper (full length) (ABIN7877760)

Target: Calpain

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Calpain Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: CAPN1-1530

Produktdetails anti-Calpain Antikörper

Bindungsspezifität: full length

Verwendungszweck: Calpain Antibody / CAPN1

Aufreinigung: Protein G affinity chromatography

Immunogen: A recombinant full-length human CAPN1 protein was used as the immunogen for this Calpain antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Calpain antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Calpain antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Calpain

Target: Calpain

Hintergrund: Calpain 1 is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+- dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpain 1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.

UniProt: P07384