Filaggrin Antikörper (AA 998-1104) (Biotin)

Produktnummer ABIN7877301

Der Maus Monoklonal anti-Filaggrin Antikörper wird verwendet zum Nachweis von Filaggrin in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Filaggrin Antikörper (AA 998-1104) (Biotin) (ABIN7877301)

Target: Filaggrin (FLG)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Filaggrin Antikörper ist konjugiert mit Biotin

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: FLG-1563

Produktdetails anti-Filaggrin Antikörper (Biotin)

Bindungsspezifität: AA 998-1104

Verwendungszweck: Filaggrin Antibody

Aufreinigung: Protein G affinity chromatography

Immunogen: A portion of amino acids 998-1104 from the human protein was used as the immunogen for the Filaggrin antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Filaggrin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Filaggrin antibody at 2-8oC (up to one month) or aliquot and store at -20oC (longer term).

Details zu Filaggrin

Target: Filaggrin (FLG)

Andere Bezeichnung: Filaggrin

Hintergrund: Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

UniProt: P20930

Pathways: Sensory Perception of Sound, Stem Cell Maintenance