SYCP1 Antikörper (AA 95-717)

Produktnummer ABIN7877226

Der Kaninchen Polyklonal anti-SYCP1 Antikörper wird verwendet zum Nachweis von SYCP1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und ELISA.

Kurzübersicht für SYCP1 Antikörper (AA 95-717) (ABIN7877226)

Target: SYCP1 (Synaptonemal Complex Protein 1 (SYCP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SYCP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-SYCP1 Antikörper

Bindungsspezifität: AA 95-717

Verwendungszweck: SYCP1 Antibody / Synaptonemal complex protein 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human SYCP1 recombinant protein (Position: D95-H717) was used as the immunogen for the SYCP1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SYCP1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SYCP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SYCP1

Target: SYCP1 (Synaptonemal Complex Protein 1 (SYCP1))

Andere Bezeichnung: SYCP1

Hintergrund: SYCP1 antibody detects Synaptonemal complex protein 1, encoded by the SYCP1 gene. Synaptonemal complex protein 1 is a structural protein that forms the transverse filaments of the synaptonemal complex during meiosis. SYCP1 antibody provides researchers with a specific reagent for studying meiotic chromosome pairing, synapsis, and fertility.

Synaptonemal complex protein 1 plays a fundamental role in meiotic prophase I. Research using SYCP1 antibody has shown that it bridges homologous chromosomes by connecting lateral elements composed of SYCP2 and SYCP3. This zipper-like structure stabilizes pairing and promotes homologous recombination, ensuring proper segregation of chromosomes. Without SYCP1, homologous pairing fails, leading to meiotic arrest and infertility.

Studies with SYCP1 antibody have revealed that disruption of synaptonemal complex protein 1 causes sterility in both male and female model organisms. In humans, variants in SYCP1 have been linked to cases of infertility, demonstrating its conserved role in reproductive biology. Its structural role makes SYCP1 a key marker for meiotic progression.

Beyond meiosis, SYCP1 has been used as a biomarker for germ cell development. Research using SYCP1 antibody has shown that its expression is restricted to meiotic cells, allowing it to be used as a reliable marker for spermatogenesis and oogenesis studies. This makes SYCP1 antibody a valuable tool for developmental and reproductive biology research.

SYCP1 antibody is widely applied in immunohistochemistry, immunofluorescence, and western blotting. Immunohistochemistry highlights expression in testis and ovary, immunofluorescence demonstrates localization along meiotic chromosomes, and western blotting quantifies expression during gametogenesis. These applications make SYCP1 antibody indispensable for meiosis research.

By providing validated SYCP1 antibody reagents, NSJ Bioreagents supports studies into meiotic recombination, synaptonemal complex assembly, and infertility. Detection of Synaptonemal complex protein 1 provides researchers with insight into how meiotic structures safeguard chromosome segregation.

UniProt: Q15431