STRIP1 Antikörper (AA 93-511)

Produktnummer ABIN7877185

Der Kaninchen Polyklonal anti-STRIP1 Antikörper (ABIN7877185) detektiert spezifisch STRIP1 in WB, FACS, IHC, ELISA und IP. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für STRIP1 Antikörper (AA 93-511) (ABIN7877185)

Target: STRIP1 (Striatin Interacting Protein 1 (STRIP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STRIP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Produktdetails anti-STRIP1 Antikörper

Bindungsspezifität: AA 93-511

Verwendungszweck: STRIP1 Antibody / Striatin-interacting protein 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human STRIP1 recombinant protein (Position: E93-Q511) was used as the immunogen for the STRIP1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the STRIP1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the STRIP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu STRIP1

Target: STRIP1 (Striatin Interacting Protein 1 (STRIP1))

Andere Bezeichnung: STRIP1

Hintergrund: STRIP1 antibody detects Striatin-interacting protein 1, a core component of the STRIPAK complex that integrates signaling, cytoskeletal organization, and cell migration. STRIP1 acts as a scaffold linking the PP2A phosphatase complex with kinases, adaptors, and actin-regulating proteins. The STRIP1 antibody is widely used in cell signaling, neurobiology, and cancer research to study cytoskeletal remodeling, phosphatase signaling, and morphogenesis.

STRIP1 is encoded by the STRIP1 gene located on human chromosome 3q22.1. The protein is approximately 837 amino acids long and forms stable interactions with striatin, PP2A, MOB4, and kinases of the GCKIII family. STRIP1 localizes to both cytoplasmic and cortical compartments, particularly in regions of actin remodeling and cell junctions.

The STRIP1 antibody detects a 95 kilodalton protein by western blot and exhibits perinuclear and cortical staining by immunofluorescence microscopy. STRIP1 regulates the activity of PP2A-dependent phosphatase signaling pathways that control cell polarity, adhesion, and migration. It acts in concert with STRN3 and STRN4 to modulate kinases such as STK24 and STK25, thereby maintaining cytoskeletal balance and tissue architecture.

Disruption of STRIP1 impairs cell migration and polarity, leading to developmental abnormalities and cancer metastasis. Studies show that loss of STRIP1 alters actin stress fiber organization and cell junction stability, while overexpression promotes invasive behavior in tumor cells. In neurons, STRIP1 contributes to dendritic spine morphogenesis and synaptic plasticity through modulation of PP2A and Rho GTPase signaling.

Because STRIP1 functions as a molecular integrator connecting phosphatase signaling with cytoskeletal regulation, it serves as a crucial factor in understanding morphogenesis and disease progression. NSJ Bioreagents provides a validated STRIP1 antibody optimized for its applications, supporting research into cytoskeletal dynamics, PP2A signaling, and cancer biology.

UniProt: Q5VSL9