RANBP2 Antikörper (AA 906-2744)

Produktnummer ABIN7877130

Der Kaninchen Polyklonal anti-RANBP2 Antikörper wird verwendet zum Nachweis von RANBP2 in Proben von Human. Er wurde validiert für ELISA, WB, IHC (p), IF und FACS.

Kurzübersicht für RANBP2 Antikörper (AA 906-2744) (ABIN7877130)

Target: RANBP2 (RAN Binding Protein 2 (RANBP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RANBP2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-RANBP2 Antikörper

Bindungsspezifität: AA 906-2744

Verwendungszweck: RANBP2 Antibody

Aufreinigung: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids N906-D2744) was used as the immunogen for the RANBP2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the RANBP2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the RANBP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu RANBP2

Target: RANBP2 (RAN Binding Protein 2 (RANBP2))

Andere Bezeichnung: RANBP2

Hintergrund: RAN binding protein 2 (RANBP2) is protein which in humans is encoded by the RANBP2 gene. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. And the encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q.

UniProt: P49792

Pathways: Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus