STXBP6 Antikörper (AA 9-176)

Produktnummer ABIN7877066

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch STXBP6 in WB, ELISA, IHC und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für STXBP6 Antikörper (AA 9-176) (ABIN7877066)

Target: STXBP6 (Syntaxin Binding Protein 6 (Amisyn) (STXBP6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STXBP6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-STXBP6 Antikörper

Bindungsspezifität: AA 9-176

Verwendungszweck: STXBP6 Antibody / Syntaxin-binding protein 6

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human STXBP6 recombinant protein (Position: K9-R176) was used as the immunogen for the STXBP6 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the STXBP6 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the STXBP6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu STXBP6

Target: STXBP6 (Syntaxin Binding Protein 6 (Amisyn) (STXBP6))

Andere Bezeichnung: STXBP6

Hintergrund: STXBP6 antibody detects Syntaxin-binding protein 6, also known as Amisyn, a vesicle trafficking protein that regulates membrane fusion and neurotransmitter release. STXBP6 interacts with syntaxin family members and SNARE complexes, modulating vesicular exocytosis and endocytosis. The STXBP6 antibody is widely used in neurobiology and cell trafficking research to study synaptic regulation, vesicle dynamics, and membrane fusion events.

STXBP6 is encoded by the STXBP6 gene located on human chromosome 14q23.2. The protein is approximately 246 amino acids long and contains coiled-coil domains that facilitate interaction with syntaxins such as STX1A and STX3. STXBP6 localizes to the cytoplasm and plasma membrane, where it competes with other SNARE regulators to fine-tune exocytic activity.

The STXBP6 antibody detects a 28 kilodalton band by western blot and shows cytoplasmic and perinuclear puncta consistent with vesicle-associated localization. In neurons, STXBP6 modulates neurotransmitter release by inhibiting SNARE complex assembly under resting conditions and promoting controlled vesicle fusion upon stimulation. Beyond the nervous system, STXBP6 regulates exocytosis in endocrine and epithelial cells, influencing hormone and transporter release.

Loss or dysregulation of STXBP6 affects vesicle cycling, leading to synaptic transmission defects and altered cellular signaling. In cancer cells, altered STXBP6 expression influences migration and invasion through effects on membrane recycling and adhesion molecule trafficking. It also plays roles in insulin granule exocytosis and endosomal trafficking in non-neuronal tissues.

As a modulator of vesicle docking and fusion, STXBP6 serves as a versatile model for understanding SNARE-mediated transport and signal propagation. NSJ Bioreagents provides a validated STXBP6 antibody optimized for its applications, supporting research into synaptic physiology, secretion, and membrane dynamics.

UniProt: Q8NFX7