Ube2t Antikörper (AA 9-145)

Produktnummer ABIN7877065

Der Kaninchen Polyklonal anti-Ube2t Antikörper (ABIN7877065) detektiert spezifisch Ube2t in WB, ELISA, IF und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Ube2t Antikörper (AA 9-145) (ABIN7877065)

Target: Ube2t (Ubiquitin-Conjugating Enzyme E2T (Ube2t))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ube2t Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-Ube2t Antikörper

Bindungsspezifität: AA 9-145

Verwendungszweck: UBE2T Antibody / Ubiquitin-conjugating enzyme E2 T / HSPC150

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human UBE2T recombinant protein (Position: R9-Q145) was used as the immunogen for the UBE2T antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the UBE2T antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the UBE2T antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Ube2t

Target: Ube2t (Ubiquitin-Conjugating Enzyme E2T (Ube2t))

Andere Bezeichnung: UBE2T

Hintergrund: UBE2T antibody detects Ubiquitin-conjugating enzyme E2 T, encoded by the UBE2T gene. Ubiquitin-conjugating enzyme E2 T is a member of the E2 family of enzymes that catalyze the transfer of ubiquitin to target proteins, particularly in the context of the Fanconi anemia DNA repair pathway. UBE2T antibody provides researchers with a critical reagent for studying ubiquitin signaling, DNA repair, and cancer.

Ubiquitin-conjugating enzyme E2 T functions as the cognate E2 for FANCL, the E3 ligase of the Fanconi anemia core complex. Research using UBE2T antibody has shown that it is required for monoubiquitination of FANCD2 and FANCI, a critical step in the repair of DNA interstrand crosslinks. This activity ensures faithful DNA replication and genome stability.

Studies with UBE2T antibody have revealed that loss of UBE2T function causes Fanconi anemia, a rare genetic disorder characterized by bone marrow failure, congenital abnormalities, and cancer predisposition. Patient mutations in UBE2T impair its ubiquitin conjugating activity, preventing activation of FANCD2 and disrupting DNA repair. These findings emphasize the clinical importance of UBE2T in genome maintenance.

Beyond Fanconi anemia, dysregulation of Ubiquitin-conjugating enzyme E2 T has been associated with cancer progression. Research using UBE2T antibody has shown that overexpression promotes proliferation, survival, and resistance to DNA-damaging therapies in breast, lung, and liver cancers. This suggests potential as both a biomarker and therapeutic target.

UBE2T antibody is widely applied in western blotting, immunohistochemistry, and functional repair assays. Western blotting detects monoubiquitination of FANCD2, immunohistochemistry demonstrates tumor-associated expression, and repair assays confirm participation in crosslink repair. These applications make UBE2T antibody indispensable in DNA repair and cancer biology.

By providing validated UBE2T antibody reagents, NSJ Bioreagents supports studies into ubiquitination, DNA repair, and disease. Detection of Ubiquitin-conjugating enzyme E2 T provides researchers with insight into how ubiquitin pathways regulate genome stability and cancer progression.

UniProt: Q9NPD8

Pathways: Chromatin Binding