NAV3 Antikörper (AA 9-1417)

Produktnummer ABIN7877064

Der Kaninchen Polyklonal anti-NAV3 Antikörper wird verwendet zum Nachweis von NAV3 in Proben von Human. Er wurde validiert für WB und ELISA.

Kurzübersicht für NAV3 Antikörper (AA 9-1417) (ABIN7877064)

Target: NAV3 (Neuron Navigator 3 (NAV3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NAV3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-NAV3 Antikörper

Bindungsspezifität: AA 9-1417

Verwendungszweck: NAV3 Antibody / Neuron navigator 3

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human NAV3 recombinant protein (Position: K9-D1417) was used as the immunogen for the NAV3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the NAV3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the NAV3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu NAV3

Target: NAV3 (Neuron Navigator 3 (NAV3))

Andere Bezeichnung: NAV3

Hintergrund: NAV3 antibody detects Neuron navigator 3, a cytoskeletal-associated protein that regulates axon guidance, neuronal migration, and cytoskeletal organization. Encoded by the NAV3 gene on chromosome 12q21.2, this protein belongs to the neuron navigator family, which also includes NAV1 and NAV2, and is characterized by coiled-coil and calponin homology domains that facilitate interaction with microtubules and actin filaments. NAV3 plays a pivotal role in neuronal development and guidance by stabilizing the cytoskeleton and modulating microtubule dynamics during axon extension.

NAV3 localizes primarily to neuronal growth cones and extending axons, where it influences the assembly and organization of cytoskeletal networks required for directional growth. It interacts with signaling molecules involved in cytoskeletal regulation, including Rho GTPases and kinases that modulate actin-microtubule coordination. Beyond its developmental roles, NAV3 contributes to cytoskeletal remodeling in mature neurons and glial cells, supporting plasticity and response to injury.

The NAV3 antibody is used in neuroscience and developmental biology research to study axon formation, neuronal polarity, and migration. Western blot analysis identifies a 250 kilodalton band corresponding to NAV3, while immunofluorescence reveals punctate and filamentous staining along axons and dendritic processes. This antibody enables detailed visualization of cytoskeletal organization and neuronal network formation.

Altered NAV3 expression is associated with neurodevelopmental disorders, epilepsy, and gliomas, where disrupted cytoskeletal control affects cell morphology and migration. Additionally, NAV3 has been linked to wound healing and skin differentiation, as its expression is upregulated during keratinocyte migration. The NAV3 antibody provides a robust tool for analyzing cytoskeletal guidance mechanisms and neuronal development. NSJ Bioreagents offers this antibody validated for its applications, ensuring reproducible performance in studies of neuronal and cytoskeletal regulation.

UniProt: Q8IVL0