MBNL1 Antikörper (AA 89-388)

Produktnummer ABIN7877057

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MBNL1 in WB, ELISA, IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte und Affe.

Kurzübersicht für MBNL1 Antikörper (AA 89-388) (ABIN7877057)

Target: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MBNL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-MBNL1 Antikörper

Bindungsspezifität: AA 89-388

Verwendungszweck: Muscleblind-like 1 Antibody / MBNL1

Aufreinigung: Affinity purified

Immunogen: Recombinant human protein (amino acids Q89-M388) was used as the immunogen for the Muscleblind-like 1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Muscleblind-like 1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Muscleblind-like 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu MBNL1

Target: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Andere Bezeichnung: Muscleblind-like 1

Hintergrund: Muscleblind-like (Drosophila), also known as MBNL1, is a protein that in humans is encoded by the MBNL1 gene. It is mapped to 3q25.1-q25.2. This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities.

UniProt: Q9NR56

Pathways: Ribonucleoprotein Complex Subunit Organization