ELP2 Antikörper (AA 84-826)

Produktnummer ABIN7876963

Der Kaninchen Polyklonal anti-ELP2 Antikörper (ABIN7876963) detektiert spezifisch ELP2 in ELISA, WB, IF, FACS und ICC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für ELP2 Antikörper (AA 84-826) (ABIN7876963)

Target: ELP2 (Elongator Acetyltransferase Complex Subunit 2 (ELP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ELP2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Produktdetails anti-ELP2 Antikörper

Bindungsspezifität: AA 84-826

Verwendungszweck: ELP2 Antibody / Elongator complex protein 2

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human ELP2 recombinant protein (Position: D84-L826) was used as the immunogen for the ELP2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ELP2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the ELP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu ELP2

Target: ELP2 (Elongator Acetyltransferase Complex Subunit 2 (ELP2))

Andere Bezeichnung: ELP2

Hintergrund: ELP2 antibody detects Elongator complex protein 2, encoded by the ELP2 gene. Elongator complex protein 2 is a subunit of the six-protein Elongator complex, which functions in transcriptional elongation, tRNA modification, and cytoskeletal regulation. ELP2 antibody provides researchers with a reagent for studying transcriptional control, RNA modification, and neuronal development.

The Elongator complex associates with RNA polymerase II and facilitates transcriptional elongation by modifying chromatin and RNA. Research using ELP2 antibody has shown that Elongator promotes efficient transcription of genes involved in development and stress responses. It also plays an important role in acetylation of histones, linking transcription to chromatin structure.

Studies with ELP2 antibody have revealed that Elongator regulates wobble base modifications in tRNA, ensuring accurate translation and proteome stability. Loss of ELP2 disrupts codon decoding and protein synthesis, impairing cellular growth and differentiation. These functions underscore its significance beyond transcriptional control.

Dysregulation of Elongator complex protein 2 has been associated with neurodevelopmental and neurological disorders. Research using ELP2 antibody has shown that variants in Elongator subunits contribute to familial dysautonomia and intellectual disability syndromes. In neuronal systems, ELP2 influences migration, axonal outgrowth, and synaptic development, highlighting its role in brain function.

Beyond neurology, Elongator impacts immune responses and tumor biology. Research using ELP2 antibody has indicated that altered expression affects stress-induced gene expression, cell migration, and invasion in cancer. These findings expand its biological scope.

ELP2 antibody is widely applied in western blotting, immunohistochemistry, and RNA-protein interaction studies. Western blotting quantifies protein levels in tissues, immunohistochemistry demonstrates localization, and interaction studies identify Elongator-associated RNAs and proteins. These applications make ELP2 antibody indispensable for research in transcriptional and translational regulation.

By providing validated ELP2 antibody reagents, NSJ Bioreagents supports studies into transcriptional elongation, tRNA modification, and neurodevelopment. Detection of Elongator complex protein 2 provides researchers with insight into how transcriptional cofactors regulate gene expression and disease.

UniProt: Q6IA86

Pathways: Stem Cell Maintenance, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus