SNX16 Antikörper (AA 84-344)

Produktnummer ABIN7876956

Der Kaninchen Polyklonal anti-SNX16 Antikörper wird verwendet zum Nachweis von SNX16 in Proben von Human, Maus und Ratte. Er wurde validiert für ELISA, WB, IHC, FACS, ICC und IF.

Kurzübersicht für SNX16 Antikörper (AA 84-344) (ABIN7876956)

Target: SNX16 (Sorting Nexin 16 (SNX16))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNX16 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)

Produktdetails anti-SNX16 Antikörper

Bindungsspezifität: AA 84-344

Verwendungszweck: SNX16 Antibody / Sorting nexin-16

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human SNX16 recombinant protein (Position: I84-D344) was used as the immunogen for the SNX16 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SNX16 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SNX16 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SNX16

Target: SNX16 (Sorting Nexin 16 (SNX16))

Andere Bezeichnung: SNX16

Hintergrund: SNX16 antibody detects Sorting nexin-16, a phosphoinositide-binding protein that regulates endosomal trafficking, membrane remodeling, and receptor recycling. SNX16 belongs to the sorting nexin family, which is characterized by the presence of a phox homology (PX) domain that interacts with phosphatidylinositol 3-phosphate-enriched membranes. The SNX16 antibody is widely used in cell biology and neurobiology research to investigate endosome organization and cargo transport.

SNX16 is encoded by the SNX16 gene located on human chromosome 8p21.3. The protein is approximately 62 kilodaltons and localizes primarily to early endosomes. It participates in the formation of tubular endosomal structures that mediate receptor sorting between degradation and recycling pathways. SNX16 functions independently of the retromer complex and instead promotes membrane tubulation through its coiled-coil domain. It regulates trafficking of receptors such as EGFR and TrkB, influencing growth factor signaling and neuronal development.

The SNX16 antibody typically identifies a 40-50 kilodalton protein by western blot and demonstrates punctate cytoplasmic staining characteristic of endosomal localization. Functional studies show that depletion of SNX16 disrupts endosomal tubulation, alters cargo recycling, and can impair signaling pathways dependent on receptor localization. Overexpression of SNX16 enhances endosomal membrane curvature and promotes receptor clustering, demonstrating its mechanochemical role in shaping endosomes.

In neurons, SNX16 contributes to dendritic spine maintenance and receptor turnover, impacting synaptic plasticity. It may also participate in autophagy regulation through endosome-lysosome fusion. Aberrant SNX16 expression has been linked to neurodegenerative disorders and cancer, where altered trafficking pathways contribute to signaling dysregulation. NSJ Bioreagents offers a validated SNX16 antibody, enabling researchers to explore endosomal dynamics, cargo sorting, and signaling modulation.

UniProt: P57768