LPAR5 Antikörper (AA 83-372)

Produktnummer ABIN7876940

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch LPAR5 in WB, ELISA und FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für LPAR5 Antikörper (AA 83-372) (ABIN7876940)

Target: LPAR5 (Lysophosphatidic Acid Receptor 5 (LPAR5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LPAR5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-LPAR5 Antikörper

Bindungsspezifität: AA 83-372

Verwendungszweck: LPAR5 Antibody / Lysophosphatidic acid receptor 5

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human LPAR5 recombinant protein (Position: A83-L372) was used as the immunogen for the LPAR5 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the LPAR5 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the LPAR5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu LPAR5

Target: LPAR5 (Lysophosphatidic Acid Receptor 5 (LPAR5))

Andere Bezeichnung: LPAR5

Hintergrund: LPAR5 antibody detects Lysophosphatidic acid receptor 5, a G protein-coupled receptor (GPCR) that mediates signaling by lysophosphatidic acid (LPA), a bioactive phospholipid involved in cell proliferation, motility, and immune regulation. The UniProt recommended name is Lysophosphatidic acid receptor 5 (LPAR5). This receptor couples primarily to G12/13 and Gq proteins, triggering downstream activation of Rho and phospholipase C pathways.

Functionally, LPAR5 antibody identifies a 353-amino-acid receptor localized to the plasma membrane. LPAR5 activation induces calcium mobilization, cytoskeletal rearrangement, and cytokine release. It contributes to pain sensation, vascular permeability, and immune cell migration. In neuronal cells, LPAR5 influences axonal guidance and neuroinflammation.

The LPAR5 gene is located on chromosome 12p13.31 and is expressed in platelets, lymphocytes, dorsal root ganglia, and intestinal epithelial cells. It plays roles in both physiological and pathological processes such as wound healing, sensory transmission, and inflammation.

Pathologically, dysregulation of LPAR5 signaling has been implicated in neuropathic pain, cancer metastasis, and autoimmune diseases. Inhibition of LPAR5 reduces pain hypersensitivity and inflammatory cytokine production, making it a potential therapeutic target. Research using LPAR5 antibody supports studies in GPCR signaling, lipid biology, and inflammation.

LPAR5 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect LPA receptors. NSJ Bioreagents provides LPAR5 antibody reagents optimized for research in lipid signaling, receptor pharmacology, and immune modulation.

Structurally, Lysophosphatidic acid receptor 5 contains seven transmembrane helices and intracellular loops that couple to G proteins and scaffolding proteins. This antibody facilitates exploration of LPAR5's signaling mechanisms and receptor-mediated physiological responses.

UniProt: Q9H1C0