TRIP6 Antikörper (AA 8-476)

Produktnummer ABIN7876835

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TRIP6 in WB, ELISA, IP und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für TRIP6 Antikörper (AA 8-476) (ABIN7876835)

Target: TRIP6 (Thyroid Hormone Receptor Interactor 6 (TRIP6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIP6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Flow Cytometry (FACS)

Produktdetails anti-TRIP6 Antikörper

Bindungsspezifität: AA 8-476

Verwendungszweck: TRIP6 Antibody / Thyroid receptor-interacting protein 6

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human TRIP6 recombinant protein (Position: P8-C476) was used as the immunogen for the TRIP6 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TRIP6 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the TRIP6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu TRIP6

Target: TRIP6 (Thyroid Hormone Receptor Interactor 6 (TRIP6))

Andere Bezeichnung: TRIP6

Hintergrund: TRIP6 antibody detects Thyroid receptor-interacting protein 6, a LIM domain-containing adaptor protein that links cell adhesion and cytoskeletal structures to signal transduction and transcriptional regulation. TRIP6 is part of the zyxin family of focal adhesion proteins and regulates cell motility, survival, and mechanical signaling. The TRIP6 antibody is widely used in cell signaling, cytoskeletal, and cancer biology to study focal adhesion dynamics and transcriptional control.

TRIP6 is encoded by the TRIP6 gene located on human chromosome 7q22.1. The protein is approximately 476 amino acids long and contains three LIM domains that mediate interactions with actin-associated proteins, kinases, and transcriptional regulators. TRIP6 localizes to focal adhesions, the cytoplasm, and the nucleus, reflecting its multifunctional role in signaling and structural regulation.

The TRIP6 antibody detects a 50 kilodalton band by western blot and shows strong focal adhesion staining under immunofluorescence. TRIP6 interacts with proteins such as paxillin, LPP, and integrin-linked kinase to regulate actin remodeling and cell migration. It also functions as a coactivator of transcription factors, including NF-kappaB and AP-1, linking mechanical and inflammatory signaling pathways.

In cancer, TRIP6 is frequently overexpressed and contributes to tumor cell migration, invasion, and survival. It mediates integrin and growth factor signaling, promoting metastasis through focal adhesion turnover and epithelial-to-mesenchymal transition. Conversely, in certain cell types, TRIP6 may act as a negative regulator of apoptosis and inflammation, demonstrating context-dependent roles.

As a versatile adaptor integrating cytoskeletal and transcriptional functions, TRIP6 is an important regulator of cellular mechanics and gene expression. NSJ Bioreagents provides a validated TRIP6 antibody optimized for its applications, supporting research into cell migration, mechanotransduction, and cancer progression.

UniProt: Q15654

Pathways: Cell-Cell Junction Organization