Hexokinase Antikörper (AA 78-108)

Produktnummer ABIN7876776

Der Kaninchen Polyklonal anti-Hexokinase Antikörper wird verwendet zum Nachweis von Hexokinase in Proben von Human und Ratte. Er wurde validiert für WB und IHC (p).

Kurzübersicht für Hexokinase Antikörper (AA 78-108) (ABIN7876776)

Target: Hexokinase

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Hexokinase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Hexokinase Antikörper

Bindungsspezifität: AA 78-108

Verwendungszweck: Hexokinase Antibody / HK1

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 78-108 from the human protein was used as the immunogen for the Hexokinase antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the Hexokinase antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Hexokinase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Hexokinase

Target: Hexokinase

Hintergrund: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. The hexokinase gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of the hexokinase gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus, the remainder of the protein is identical among all the isoforms. HK1 encodes the ubiquitously expressed isoform. Its 5' end includes an exon which is unique to this transcript and which encodes a distinct N-terminus that contains the porin binding domain (PBD). The porin binding domain mediates association with the mitochondrial membrane.

UniProt: P19367