NAP1L3 Antikörper (AA 77-506)

Produktnummer ABIN7876766

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NAP1L3 in WB, ELISA und FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für NAP1L3 Antikörper (AA 77-506) (ABIN7876766)

Target: NAP1L3 (Nucleosome Assembly Protein 1-Like 3 (NAP1L3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NAP1L3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-NAP1L3 Antikörper

Bindungsspezifität: AA 77-506

Verwendungszweck: NAP1L3 Antibody / Nucleosome assembly protein 1 like 3

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human NAP1L3 recombinant protein (Position: K77-K506) was used as the immunogen for the NAP1L3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the NAP1L3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the NAP1L3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu NAP1L3

Target: NAP1L3 (Nucleosome Assembly Protein 1-Like 3 (NAP1L3))

Andere Bezeichnung: NAP1L3

Hintergrund: NAP1L3 antibody detects Nucleosome assembly protein 1 like 3, encoded by the NAP1L3 gene. Nucleosome assembly protein 1 like 3 is a histone chaperone that regulates nucleosome dynamics and chromatin organization. NAP1L3 antibody provides researchers with a specific reagent for studying chromatin remodeling, transcriptional regulation, and epigenetics.

Nucleosome assembly protein 1 like 3 belongs to the NAP family of proteins that shuttle histones between the cytoplasm and the nucleus. Research using NAP1L3 antibody has shown that it facilitates the deposition of histones H2A and H2B onto DNA, a process essential for nucleosome formation. This activity supports both DNA replication and transcription, where nucleosome remodeling is required.

Studies with NAP1L3 antibody have revealed that this protein not only mediates histone assembly but also prevents inappropriate histone-DNA interactions by acting as a histone storage factor. This regulation maintains chromatin accessibility and ensures that transcriptional programs proceed accurately. The ability of NAP1L3 to regulate histone exchange links it to transcriptional activation and repression pathways.

Dysregulation of NAP1L3 has been associated with cancer and developmental disorders. Research using NAP1L3 antibody has shown that altered expression disrupts chromatin balance, leading to misregulated gene expression. Overexpression has been observed in certain tumors, where enhanced histone assembly promotes cell proliferation. Conversely, reduced expression impairs differentiation, underscoring its importance in development.

NAP1L3 antibody is commonly used in western blotting, immunohistochemistry, and chromatin immunoprecipitation. Western blotting quantifies histone chaperone levels, immunohistochemistry identifies nuclear localization, and chromatin immunoprecipitation maps chromatin interactions. These methods make NAP1L3 antibody valuable for epigenetic and transcriptional studies.

By supplying validated NAP1L3 antibody reagents, NSJ Bioreagents supports studies into chromatin remodeling, transcriptional regulation, and disease. Detection of Nucleosome assembly protein 1 like 3 provides researchers with insight into how histone chaperones regulate gene expression and cellular development.

UniProt: Q99457