TCF20 Antikörper (AA 735-1933)

Produktnummer ABIN7876697

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TCF20 in WB, ICC, ELISA und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für TCF20 Antikörper (AA 735-1933) (ABIN7876697)

Target: TCF20 (Transcription Factor 20 (TCF20))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TCF20 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), ELISA, Immunofluorescence (IF)

Produktdetails anti-TCF20 Antikörper

Bindungsspezifität: AA 735-1933

Verwendungszweck: TCF20 Antibody / Transcription factor 20

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human TCF20 recombinant protein (Position: D735-K1933) was used as the immunogen for the TCF20 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TCF20 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the TCF20 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu TCF20

Target: TCF20 (Transcription Factor 20 (TCF20))

Andere Bezeichnung: TCF20

Hintergrund: TCF20 antibody detects Transcription factor 20, encoded by the TCF20 gene. Transcription factor 20 is a nuclear protein that regulates gene transcription by binding to promoter regions and interacting with transcriptional co-regulators. TCF20 antibody provides researchers with a specific reagent for studying transcriptional control, development, and disease processes involving altered gene expression.

Transcription factor 20 contains multiple structural domains, including DNA-binding regions, zinc finger motifs, and protein interaction modules that allow it to function as a versatile transcriptional regulator. Research using TCF20 antibody has shown that it regulates genes involved in neuronal differentiation, immune signaling, and embryonic development. Its ability to partner with transcriptional activators and repressors highlights its broad functional repertoire.

Studies with TCF20 antibody have revealed that mutations in the TCF20 gene cause neurodevelopmental disorders characterized by intellectual disability, autism spectrum features, and hypotonia. These mutations impair transcriptional regulation, leading to widespread developmental consequences. This underscores the importance of Transcription factor 20 in brain development and function.

In addition to neurodevelopmental disorders, altered expression of TCF20 has been associated with cancer. Research using TCF20 antibody has shown that abnormal levels promote dysregulated transcriptional programs that drive proliferation and survival in certain tumor types. This suggests that TCF20 contributes to oncogenesis through transcriptional misregulation.

TCF20 antibody is widely used in chromatin immunoprecipitation, western blotting, and immunohistochemistry. Chromatin immunoprecipitation identifies direct DNA binding targets, western blotting quantifies expression across tissues, and immunohistochemistry reveals nuclear localization in developmental and disease contexts. These applications make TCF20 antibody valuable in both basic and clinical research.

By supplying validated TCF20 antibody reagents, NSJ Bioreagents supports studies into transcriptional regulation, neurodevelopment, and cancer. Detection of Transcription factor 20 provides researchers with insights into how transcriptional regulators control gene expression and development.

UniProt: Q9UGU0