TRIM31 Antikörper (AA 72-335)

Produktnummer ABIN7876635

Der Kaninchen Polyklonal anti-TRIM31 Antikörper wird verwendet zum Nachweis von TRIM31 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA und FACS.

Kurzübersicht für TRIM31 Antikörper (AA 72-335) (ABIN7876635)

Target: TRIM31 (Tripartite Motif Containing 31 (TRIM31))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM31 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-TRIM31 Antikörper

Bindungsspezifität: AA 72-335

Verwendungszweck: TRIM31 Antibody / Tripartite motif-containing protein 31

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human TRIM31 recombinant protein (Position: R72-E335) was used as the immunogen for the TRIM31 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TRIM31 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the TRIM31 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu TRIM31

Target: TRIM31 (Tripartite Motif Containing 31 (TRIM31))

Andere Bezeichnung: TRIM31

Hintergrund: TRIM31 antibody detects Tripartite motif-containing protein 31, an E3 ubiquitin ligase involved in innate immune regulation, antiviral defense, and tumor suppression. TRIM31 belongs to the TRIM family, characterized by RING, B-box, and coiled-coil domains that mediate ubiquitination and protein complex assembly. The TRIM31 antibody is widely used in immunology, virology, and oncology to study ubiquitin-mediated signaling and inflammation control.

TRIM31 is encoded by the TRIM31 gene on human chromosome 6p22.1. The protein is approximately 478 amino acids long and localizes to the cytoplasm and mitochondria. TRIM31 acts as an E3 ubiquitin ligase that targets specific signaling intermediates for degradation or activation, thus modulating innate immune pathways such as RIG-I and MAVS. Through ubiquitination, TRIM31 promotes antiviral signaling by facilitating MAVS aggregation and interferon production.

The TRIM31 antibody detects a 55 kilodalton protein by western blot and demonstrates cytoplasmic punctate staining. In addition to its role in antiviral defense, TRIM31 regulates inflammasome activation and apoptosis. It ubiquitinates NLRP3 and p53, thereby controlling inflammatory and apoptotic responses. Dysregulation of TRIM31 leads to chronic inflammation and has been implicated in autoimmune diseases and metabolic disorders.

In cancer, TRIM31 can function as both an oncogene and tumor suppressor depending on cellular context. Overexpression of TRIM31 promotes proliferation and invasion in gastric and pancreatic cancers, whereas loss of TRIM31 contributes to tumorigenesis through impaired apoptosis regulation. TRIM31 expression is also linked to mitochondrial quality control via regulation of mitophagy, emphasizing its multifaceted cellular functions.

As a key E3 ligase coordinating immune, inflammatory, and metabolic pathways, TRIM31 represents a versatile model for studying ubiquitin signaling networks. NSJ Bioreagents provides a validated TRIM31 antibody optimized for its applications, supporting research into antiviral defense, protein turnover, and cancer biology.

UniProt: Q9BZY9