Tumor Suppressor ARF (CDKN2A) (AA 72-101) Antikörper

Produktnummer ABIN7876617

Der Kaninchen Polyklonal anti-Tumor Suppressor ARF Antikörper wird verwendet zum Nachweis von Tumor Suppressor ARF in Proben von Human. Er wurde validiert für IHC (p), FACS und WB.

Kurzübersicht für Tumor Suppressor ARF (CDKN2A) (AA 72-101) Antikörper (ABIN7876617)

Target: Tumor Suppressor ARF (CDKN2A)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Western Blotting (WB)

Produktdetails

Bindungsspezifität: AA 72-101

Verwendungszweck: Tumor suppressor ARF Antibody / CDKN2A / MLM

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 72-101 from the human protein was used as the immunogen for the Tumor suppressor ARF antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the Tumor suppressor ARF antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Tumor suppressor ARF antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Antigendetails

Target: Tumor Suppressor ARF (CDKN2A)

Andere Bezeichnung: Tumor suppressor ARF

Hintergrund: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

UniProt: Q8N726