MIB2 Antikörper (AA 71-572)

Produktnummer ABIN7876609

Der Kaninchen Polyklonal anti-MIB2 Antikörper (ABIN7876609) detektiert spezifisch MIB2 in WB, IP und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für MIB2 Antikörper (AA 71-572) (ABIN7876609)

Target: MIB2 (E3 ubiquitin-protein ligase MIB2 (MIB2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MIB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS)

Produktdetails anti-MIB2 Antikörper

Bindungsspezifität: AA 71-572

Verwendungszweck: MIB2 Antibody / Mindbomb 2

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids A71-I572) was used as the immunogen for the MIB2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MIB2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the MIB2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu MIB2

Target: MIB2 (E3 ubiquitin-protein ligase MIB2 (MIB2))

Andere Bezeichnung: MIB2

Hintergrund: MIB2 (Mindbomb 2) is a RING-type E3 ubiquitin ligase that regulates membrane protein turnover and signal transduction, most notably within the Notch pathway. By catalyzing ubiquitination of Delta-like ligands, MIB2 promotes their endocytosis and activation competence, ensuring proper receptor engagement and downstream transcriptional responses. Through these activities, MIB2 helps coordinate cellâ€""cell communication during development and tissue homeostasis.

Beyond canonical Notch signaling, MIB2 has been implicated in cytoskeletal organization and broader ubiquitin-mediated quality control. Altered MIB2 expression or activity can influence cell fate decisions, neural and immune system function, and tumor biology, where disrupted ligand trafficking and signaling balance contribute to disease phenotypes. Its functional overlap and divergence relative to the paralog MIB1 highlight MIB2 as a distinct regulator with tissue- and context-specific roles.

The MIB2 antibody enables specific detection of endogenous MIB2 in cells and tissues for applications including western blot, immunofluorescence, and immunohistochemistry. Researchers use the MIB2 antibody to quantify expression, assess subcellular localization at membranes and endosomes, and monitor pathway modulation under genetic or pharmacologic perturbations. With high specificity and consistent performance, the MIB2 antibody supports studies of ubiquitin signaling, Notch pathway regulation, and disease mechanisms.

UniProt: Q96AX9

Pathways: Notch Signalweg