RAB1A Antikörper (AA 71-195)

Produktnummer ABIN7876599

Der Kaninchen Polyklonal anti-RAB1A Antikörper wird verwendet zum Nachweis von RAB1A in Proben von Zebrafisch (Danio rerio). Er wurde validiert für WB und IHC (p).

Kurzübersicht für RAB1A Antikörper (AA 71-195) (ABIN7876599)

Target: RAB1A (RAB1A, Member RAS Oncogene Family (RAB1A))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAB1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-RAB1A Antikörper

Bindungsspezifität: AA 71-195

Verwendungszweck: Zebrafish Rab1a Antibody / Rab1aa / Rab1ab

Aufreinigung: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Rab1a recombinant protein (amino acids R71-T195) was used as the immunogen for the Zebrafish Rab1a antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish Rab1a antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish Rab1a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu RAB1A

Target: RAB1A (RAB1A, Member RAS Oncogene Family (RAB1A))

Andere Bezeichnung: Rab1a

Hintergrund: Rab1a is a member of the Rab GTPase family, which regulates intracellular vesicle trafficking, membrane dynamics, and cellular processes such as secretion, endocytosis, and organelle maintenance. Rab1a is primarily involved in the regulation of the endoplasmic reticulum (ER) and Golgi apparatus communication. It plays a crucial role in the anterograde transport of proteins from the ER to the Golgi, as well as in the formation of vesicles during this process. It also participates in regulating vesicle docking and fusion, key events in cellular trafficking.

In zebrafish, Rab1a is the ortholog of the human RAB1A gene, with a high degree of sequence conservation and functional similarity. Both the zebrafish and human versions of Rab1a share conserved GTP-binding domains and the mechanisms necessary for vesicle trafficking. The role of Rab1a in zebrafish mirrors its function in humans, supporting processes such as protein secretion, cellular homeostasis, and membrane transport. This functional conservation makes zebrafish an excellent model for studying vesicular trafficking mechanisms and associated diseases.

In zebrafish, Rab1a exists as Rab1aa and Rab1ab, which are paralogous genes resulting from gene duplication events. Both Rab1aa and Rab1ab encode proteins with similar functions but may exhibit tissue-specific expression patterns or slight differences in their regulatory roles. While Rab1aa and Rab1ab share high sequence homology, they might have distinct roles during development or in various physiological contexts. Isoforms of Rab1a could arise through alternative splicing, allowing for specialized functions in different tissues or developmental stages.

The Rab1a proteins, including Rab1aa and Rab1ab, play significant roles in cellular processes like vesicle formation, transport, and fusion, especially in tissues with active secretion and protein processing, such as the liver, pancreas, and neurons. These proteins are involved in maintaining the proper function of the ER and Golgi, essential for protein trafficking and cellular signaling. Their roles are particularly important in maintaining the balance of protein homeostasis in cells.

Given the high conservation between zebrafish Rab1a (including Rab1aa and Rab1ab) and human RAB1A, zebrafish serve as an ideal model for investigating the molecular basis of diseases related to defects in vesicle trafficking, such as neurodegenerative diseases, metabolic disorders, and certain types of cancer. By studying Rab1a and its paralogs, researchers can explore therapeutic strategies aimed at modulating vesicle trafficking pathways, which could help in the treatment of these diseases.

UniProt: B8JLC8

Pathways: SARS-CoV-2 Protein Interaktom