Ribonuclease H1 Antikörper (AA 7-223)

Produktnummer ABIN7876470

Der Kaninchen Polyklonal anti-Ribonuclease H1 Antikörper wird verwendet zum Nachweis von Ribonuclease H1 in Proben von Human und Maus. Er wurde validiert für WB, ELISA, IF und FACS.

Kurzübersicht für Ribonuclease H1 Antikörper (AA 7-223) (ABIN7876470)

Target: Ribonuclease H1 (RNASEH1)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ribonuclease H1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-Ribonuclease H1 Antikörper

Bindungsspezifität: AA 7-223

Verwendungszweck: Ribonuclease H1 Antibody / RNASEH1

Aufreinigung: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids L7-Q223) was used as the immunogen for the Ribonuclease H1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Ribonuclease H1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Ribonuclease H1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Ribonuclease H1

Target: Ribonuclease H1 (RNASEH1)

Andere Bezeichnung: Ribonuclease H1

Hintergrund: Ribonuclease H1 also known as RNase H1 is an enzyme that in humans is encoded by the RNASEH1 gene. This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and plays a key role in DNA replication and repair. Alternate in-frame start codon initiation results in the production of alternate isoforms that are directed to the mitochondria or to the nucleus. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF). Mutations in this gene have been found in individuals with progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2. Alternative splicing results in additional coding and non-coding transcript variants. Pseudogenes of this gene have been defined on chromosomes 2 and 17.

UniProt: O60930