Chordin Antikörper (AA 69-940)

Produktnummer ABIN7876452

Der Kaninchen Polyklonal anti-Chordin Antikörper wird verwendet zum Nachweis von Chordin in Proben von Zebrafisch (Danio rerio). Er wurde validiert für WB.

Kurzübersicht für Chordin Antikörper (AA 69-940) (ABIN7876452)

Target: Chordin (CHRD)

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Chordin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Chordin Antikörper

Bindungsspezifität: AA 69-940

Verwendungszweck: Zebrafish Chordin Antibody / Chd / Chrd

Aufreinigung: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Chordin recombinant protein (amino acids H69-H940) was used as the immunogen for the Zebrafish Chordin antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish Chordin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish Chordin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Chordin

Target: Chordin (CHRD)

Andere Bezeichnung: Chordin

Hintergrund: Chordin (also called Chd, Chrd) is a secreted glycoprotein that plays a central role in early embryonic development by antagonizing Bone Morphogenetic Protein (BMP) signaling. In zebrafish (Danio rerio), Chordin is a key dorsalizing factor that helps establish the dorsoventral axis during gastrulation, contributing to proper tissue patterning and organogenesis.

Chordin functions by binding directly to BMP ligands (such as Bmp2 and Bmp4), preventing them from interacting with their receptors and thereby inhibiting BMP signaling activity in dorsal regions of the embryo. The zebrafish chordin gene is expressed in the organizer region (shield) during early development, and its activity is essential for the formation of dorsal structures such as the notochord, neural plate, and somites.

Loss-of-function mutations in chordin lead to ventralized phenotypes, while overexpression can result in dorsalization, underscoring its importance as a morphogen regulator. Due to its highly conserved function across vertebrates, zebrafish Chordin is widely used in studies of axis specification, morphogen gradients, neural induction, and BMP pathway modulation.

UniProt: O57472