TCF12 Antikörper (AA 67-300)

Produktnummer ABIN7876373

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TCF12 in WB, ELISA und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für TCF12 Antikörper (AA 67-300) (ABIN7876373)

Target: TCF12 (Transcription Factor 12 (TCF12))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TCF12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-TCF12 Antikörper

Bindungsspezifität: AA 67-300

Verwendungszweck: TCF12 Antibody / Transcription factor 12

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human HEB/TCF12 recombinant protein (Position: S67-G300) was used as the immunogen for the TCF12 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TCF12 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the TCF12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu TCF12

Target: TCF12 (Transcription Factor 12 (TCF12))

Andere Bezeichnung: TCF12

Hintergrund: TCF12 antibody detects Transcription factor 12, encoded by the TCF12 gene. Transcription factor 12 is a basic helix-loop-helix transcription factor that regulates gene expression during development, differentiation, and tissue homeostasis. TCF12 antibody provides researchers with a specific reagent for studying transcriptional regulation, developmental pathways, and disease mechanisms involving abnormal transcription factor activity.

Transcription factor 12 dimerizes with other basic helix-loop-helix proteins to bind E-box DNA sequences and regulate gene transcription. Research using TCF12 antibody has shown that it partners with proteins such as E47, E12, and MyoD to control cell fate decisions. Through these interactions, TCF12 coordinates gene networks that drive muscle differentiation, neural development, and hematopoiesis.

Studies with TCF12 antibody have revealed that it is essential in neural crest development, craniofacial morphogenesis, and myogenesis. Mutations in the TCF12 gene cause craniosynostosis, a disorder characterized by premature fusion of cranial sutures. This highlights the importance of Transcription factor 12 in skeletal and craniofacial development. Its broad role in embryonic patterning underscores its significance in developmental biology.

In cancer research, dysregulation of TCF12 contributes to oncogenesis. Research using TCF12 antibody has shown that aberrant expression promotes epithelial-mesenchymal transition, migration, and invasion in cancers such as glioblastoma and colorectal carcinoma. By altering transcriptional programs, TCF12 contributes to tumor progression and poor clinical outcomes.

Beyond cancer, TCF12 has been linked to immune function. Studies with TCF12 antibody have revealed that it regulates lymphocyte development and differentiation. By controlling gene expression in immune progenitors, Transcription factor 12 ensures proper immune cell lineage commitment and functional competence. This expands its relevance to immunology.

TCF12 antibody is widely applied in chromatin immunoprecipitation, western blotting, and immunohistochemistry. Chromatin immunoprecipitation identifies DNA targets, western blotting quantifies protein expression, and immunohistochemistry reveals nuclear localization in tissue. These approaches make TCF12 antibody a versatile tool in developmental and disease biology.

By supplying validated TCF12 antibody reagents, NSJ Bioreagents supports studies into transcriptional control, development, and pathology. Detection of Transcription factor 12 provides researchers with insight into how helix-loop-helix proteins regulate gene expression across diverse biological systems.

UniProt: Q99081

Pathways: SARS-CoV-2 Protein Interaktom