SYNPO2L Antikörper (AA 66-923)

Produktnummer ABIN7876352

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SYNPO2L in WB, ELISA und FACS. Es zeigt Reaktivität gegenüber Proben von Human und Ratte.

Kurzübersicht für SYNPO2L Antikörper (AA 66-923) (ABIN7876352)

Target: SYNPO2L (Synaptopodin 2-Like (SYNPO2L))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SYNPO2L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-SYNPO2L Antikörper

Bindungsspezifität: AA 66-923

Verwendungszweck: SYNPO2L Antibody / Synaptopodin 2-like protein

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human SYNPO2L recombinant protein (Position: H66-E923) was used as the immunogen for the SYNPO2L antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SYNPO2L antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SYNPO2L antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SYNPO2L

Target: SYNPO2L (Synaptopodin 2-Like (SYNPO2L))

Andere Bezeichnung: SYNPO2L

Hintergrund: SYNPO2L antibody detects Synaptopodin 2-like protein, an actin-binding cytoskeletal protein associated with cardiac and skeletal muscle structure and function. Encoded by the SYNPO2L gene on chromosome 10q22.2, this protein is part of the synaptopodin family and contributes to sarcomere organization, Z-disc stability, and myofibril assembly. SYNPO2L localizes to actin stress fibers and the Z-discs of cardiomyocytes, where it plays a key role in linking the actin cytoskeleton to contractile apparatus components.

Structurally, SYNPO2L contains actin-binding domains and proline-rich motifs that mediate interaction with alpha-actinin and other cytoskeletal proteins. It helps anchor signaling molecules at Z-discs, coordinating mechanical and biochemical responses during muscle contraction and adaptation. Through its role in actin filament organization, SYNPO2L contributes to cardiomyocyte differentiation and maintenance of sarcomere integrity.

The SYNPO2L antibody is widely used in cardiovascular and muscle research to study cytoskeletal architecture, myofibril assembly, and Z-disc organization. Western blot analysis detects a 110 kilodalton band corresponding to SYNPO2L, while immunofluorescence shows striated staining patterns characteristic of sarcomeric proteins. This antibody is valuable for investigating the molecular mechanisms of cardiac development, contractile regulation, and myopathy pathogenesis.

Genetic variants in SYNPO2L are associated with atrial fibrillation and cardiomyopathy, suggesting its importance in cardiac conduction and mechanical stability. Altered expression of SYNPO2L may also affect stress fiber organization in non-muscle cells, influencing cell migration and adhesion. The SYNPO2L antibody supports studies of muscle structure, cytoskeletal signaling, and heart disease mechanisms. NSJ Bioreagents provides this antibody validated for its applications, ensuring accuracy in studies of cytoskeletal and cardiac biology.

UniProt: Q9H987