APOH Antikörper (AA 592-689)

Produktnummer ABIN7875928

Der Maus Monoklonal anti-APOH Antikörper (Klon APOH-3705) (ABIN7875928) detektiert spezifisch APOH in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für APOH Antikörper (AA 592-689) (ABIN7875928)

Target: APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser APOH Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: APOH-3705

Produktdetails anti-APOH Antikörper

Bindungsspezifität: AA 592-689

Verwendungszweck: APOH Antibody / Apolipoprotein H

Aufreinigung: Protein A/G affinity

Immunogen: A human recombinant Apolipoprotein H protein fragment (within amino acids 592-689) was used as the immunogen for the APOH antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the APOH antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the APOH antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu APOH

Target: APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))

Andere Bezeichnung: APOH

Hintergrund: Human apolipoprotein H (apoH, also designated b2-glycoprotein I, activated protein C binding protein or APC inhibitor) is a five-domain plasma membrane-adhesion protein that is rich in sialic acid linked a to galactose or N-acetylgal-actosamine. apoH has been implicated in a variety of physiological pathways, including blood coagulation and the immune response. apoH is a cofactor for the binding of serum auto-antibodies from antiphospholipid syndrome, and is correlated with thrombosis, lupus erythematosus and recurrent fetal loss. In addition, apoH is also implicated in the clearance of apoptotic bodies from the circulation. The apoH gene is located on human chromosome 17q24.2. apoH is synthesized by hepatocytes and is present in blood associated with plasma lipoproteins. apoH displays a genetically determined structural polymorphism including three alleles (apoH*1, apoH*2 and apoH*3). apoH can inhibit the translocation of cholesterol from extracellular pools to macrophages, which reduces the cellular accumulation of cholesterol, suggesting that apoH may play an important role in the prevention of atherosclerosis.

UniProt: P02749