PITPNC1 Antikörper (AA 59-332)

Produktnummer ABIN7875901

Der Kaninchen Polyklonal anti-PITPNC1 Antikörper (ABIN7875901) detektiert spezifisch PITPNC1 in ELISA, WB und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PITPNC1 Antikörper (AA 59-332) (ABIN7875901)

Target: PITPNC1 (Phosphatidylinositol Transfer Protein, Cytoplasmic 1 (PITPNC1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PITPNC1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-PITPNC1 Antikörper

Bindungsspezifität: AA 59-332

Verwendungszweck: PITPNC1 Antibody / Phosphatidylinositol transfer protein cytoplasmic 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human PITPNC1 recombinant protein (Position: E59-E332) was used as the immunogen for the PITPNC1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PITPNC1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the PITPNC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PITPNC1

Target: PITPNC1 (Phosphatidylinositol Transfer Protein, Cytoplasmic 1 (PITPNC1))

Andere Bezeichnung: PITPNC1

Hintergrund: The PITPNC1 antibody targets Phosphatidylinositol transfer protein, cytoplasmic 1, an intracellular lipid-binding protein encoded by the PITPNC1 gene. This protein regulates phosphoinositide signaling and lipid transport between membrane compartments. Phosphatidylinositol transfer protein, cytoplasmic 1 contributes to Golgi function, vesicular trafficking, and lipid-mediated signaling cascades. The PITPNC1 antibody enables specific detection of this protein in studies exploring cell signaling, membrane dynamics, and cancer metastasis.

Phosphatidylinositol transfer protein, cytoplasmic 1 binds phosphatidylinositol (PI) and phosphatidic acid (PA) and facilitates lipid exchange between Golgi and plasma membranes. It helps maintain phosphoinositide composition essential for vesicle budding and membrane identity. The PITPNC1 antibody supports localization studies revealing its enrichment at Golgi membranes and cytoplasmic vesicles. Through regulation of phosphoinositide pools, PITPNC1 coordinates signaling events that control secretion and membrane remodeling.

Recent research has shown that elevated PITPNC1 expression enhances tumor cell secretion and metastasis by increasing Golgi activity and secretion of pro-invasive factors such as MMP1 and HTRA1. The PITPNC1 antibody is a crucial reagent for investigating these mechanisms and assessing protein levels in metastatic cancer tissues. Its detection enables evaluation of how lipid signaling supports tumor cell migration and invasion through altered vesicle trafficking.

Phosphatidylinositol transfer protein, cytoplasmic 1 also functions in insulin secretion and lipid homeostasis, highlighting its importance beyond oncology. The PITPNC1 antibody supports studies into these metabolic processes by enabling detection in endocrine cells and liver tissues. Altered PITPNC1 expression may influence lipid droplet formation and phosphatidylinositol-dependent signaling in metabolic diseases.

The PITPNC1 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, providing characteristic Golgi-associated staining. NSJ Bioreagents supplies this antibody with validated specificity and reproducibility for use in membrane biology, cancer, and lipid metabolism research. By enabling detailed investigation of Phosphatidylinositol transfer protein, cytoplasmic 1, the PITPNC1 antibody advances understanding of lipid trafficking, secretion control, and phosphoinositide signaling in physiology and disease.

UniProt: Q9UKF7

Pathways: Inositol Metabolic Process