DGCR8 Antikörper (AA 570-771)

Produktnummer ABIN7875818

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch DGCR8 in IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Zebrafisch (Danio rerio).

Kurzübersicht für DGCR8 Antikörper (AA 570-771) (ABIN7875818)

Target: DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DGCR8 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-DGCR8 Antikörper

Bindungsspezifität: AA 570-771

Verwendungszweck: Zebrafish Dgcr8 Antibody

Aufreinigung: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Dgcr8 recombinant protein (amino acids K570-Q771) was used as the immunogen for the Zebrafish Dgcr8 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish Dgcr8 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish Dgcr8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu DGCR8

Target: DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))

Andere Bezeichnung: Dgcr8

Hintergrund: Dgcr8, or DiGeorge syndrome critical region gene eight, is a double stranded RNA binding protein that plays a key role in the microRNA processing pathway. In zebrafish, Dgcr8 is an essential component of the microprocessor complex, which includes the ribonuclease enzyme Drosha. Together, they initiate the first step in converting primary microRNA transcripts into precursor microRNAs, which are further processed into mature microRNAs.

MicroRNAs are short noncoding RNAs that regulate gene expression by targeting messenger RNAs for degradation or translational repression. Dgcr8 is crucial for maintaining proper levels of microRNAs, which are involved in numerous biological processes including early development, cell differentiation, neurogenesis, and organ formation.

In zebrafish, Dgcr8 is expressed during early embryogenesis and is required for normal development of the brain, heart, and other organs. Loss of Dgcr8 function results in widespread defects due to disrupted microRNA biogenesis. Because of its evolutionary conservation and central role in RNA regulation, zebrafish Dgcr8 is widely used in studies of gene expression control, developmental biology, and disease models related to microRNA dysfunction.

UniProt: A2BEG3

Pathways: Regulatorische RNA Pathways