ACTN2 Antikörper (AA 557-692)

Produktnummer ABIN7875735

Der Maus Monoklonal anti-ACTN2 Antikörper wird verwendet zum Nachweis von ACTN2 in Proben von Human. Er wurde validiert für WB und IHC (p).

Kurzübersicht für ACTN2 Antikörper (AA 557-692) (ABIN7875735)

Target: ACTN2 (Actinin, alpha 2 (ACTN2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ACTN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: ACTN2-3294

Produktdetails anti-ACTN2 Antikörper

Bindungsspezifität: AA 557-692

Verwendungszweck: Actinin Alpha 2 Antibody / Sarcomeric Alpha Actinin / ACTN2

Aufreinigung: Protein G affinity chromatography

Immunogen: Amino acids 557-692 from the human protein were used as the immunogen for this ACTN2 antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Actinin Alpha 2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Actinin Alpha 2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu ACTN2

Target: ACTN2 (Actinin, alpha 2 (ACTN2))

Andere Bezeichnung: Actinin Alpha 2

Hintergrund: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.

UniProt: P35609

Pathways: Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity